UFR : PHARMACIE GRENOBLE

Nom : NICOLLE

Prénom : Edwige

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Equipe de recherche

•  Intitulé : ChemMed / Département de Pharmacochimie Moléculaire (DPM)
• Numéro : UMR CNRS 5063
• Thématiques : Medicinal chemistry. QSAR Studies of polyphenol derivatives. Pharmacomodulation of flavonoids. Molecular interactions of polyphenol derivatives with membrane receptors targeted to antimitotic action, ABC protein modulatory action, metalloenzymes inhibitory action.

Principales publications

1. Boumendjel A, Nicolle E, Carrupt P.-A, Boccard J, Blanc M, Geze A, Choisnard L, Wouessidgewe D, Dumontet C., 2008. Antimitotic and antiproliferative activities of chalcones: Forward structure-activity relationship. J. Med. Chem. 51, 2307-2310.
2. Ottaviani G, Martel S., Escarala C., Nicolle E., Carrupt P.-A. 2008.    The PAMPA technique as a HTS tool for partition coefficients determination in different solvent/water systems. Eur. J. Pharm. Sci., 35(1-2), 68-75.
3. Boccard J., Bajot, F., Di Pietro A., Rudaz S., Boumendje, A., Nicolle E., Carrupt P.-A., 2009. A 3D Solvatochromic Analysis of Molecular Interaction Forces Between Flavonoid Derivatives and P-glycoprotein. Eur. J. Pharm. Sci. 36, 254-264.
4. Nicolle E., Boccard J., Guilet D., Dijoux M.-G., Zelefac E., Macalou S., Schmidt J., Carrupt P.-A., Di Pietro A., Boumendjel A. 2009.  Breast Cancer Resistance Protein (BCRP, ABCG2): New Inhibitors and QSAR Studies by 3D Solvatochromic Analysis. Eur. J. Pharm. Sci. 38, 39-46.
5. Nicolle E., Boumendjel A., Macalou S. , Belkacem A.-B. , Carrupt P.-A. , Di Pietro A. 2009. QSAR Analysis and Molecular Modeling of ABCG2 Specific Inhibitors. Drug. Deliv. Rev., 61, 34-46.
6. Nicolle E., Souard F., Faure P., Boumendjel A. 2011. Flavonoids as promising lead compounds in type 2 diabetes mellitus: molecules of interest and structure-activity relationship. Curr. Med. Chem., 17, 2661-72.